Ioniplex® & Mitochondrial Health

Apr 27, 2017

Ioniplex translocates rapidly through cellular membranes which makes it highly bioavailable. Inside cells, it is capable of stimulating mitochondrial metabolism by up to 50%. Thus, Ioniplex appears to protect and enhance cellular health in two distinct ways: by gaining better access to cells and by increasing the metabolic rate of mitochondria.

About Ioniplex

Ioniplex is a proprietary plant mineral extract, containing upwards of 65 major, minor and trace minerals, which are sourced from unique mineraloid veins located throughout North America. Millions of years ago, these areas were lush with vegetation, that overtime, were compressed into the earth- forming carbon-based compounds known as “humates” or “humic substances” that are rich in minerals and fulvic acid. Mineral BioSciences® (MBS) carefully identifies, segregates and recovers this material and transports it to our state of the art facility in Goodyear, Arizona. Here it undergoes a complex, patented organic extraction process9 where the mineral rich fulvic material is extracted from the humic. The resultant product is analytically tested for quality assurance, then stored in bulk to eventually be bottled or dehydrated into a water-soluble powder, for use in a broad spectrum of health and personal care products.

Ioniplex contains naturally occurring fulvic acid, the result is an ionic material full of electrolytes, macro and micro-nutrients for optimal health. Some of the benefits of fulvic acid are: enhanced nutrient absorption, improved immune support and performance as a chelation agent.

Ioniplex & Mitochondrial Health

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plural noun

Mitochondria are an integral part of a cell and are responsible for metabolizing, or breaking down, carbohydrates and fatty acids in order to generate energy.

Mitochondrial health and metabolism is essential for the overall healthy condition of the body, especially since mitochondrial metabolic activity and number decreases with age. Several in vivo studies have shown Ioniplex’s ability to promote mitochondrial metabolism. These results are consistent with the notion of Ioniplex having beneficial activity towards maintaining mitochondrial health.

Finally, the gene expression profiling of Ioniplex treated cells revealed an overwhelming stimulation of genes involved in aerobic energy production.

Description of Test: Mitochondrial Metabolism
Report 466A

Ioniplex was added to the popular muscle enhancement product, Ensure® to determine if it would increase metabolic activity in the mitochondria, more so than the standalone product, which acted as the control. To test this theory, cells were incubated either with only Ensure or with Ensure and Ioniplex.


Cells incubated with only Ensure (Fig 3 – Panel B) generated less metabolic activity than cells incubated with Ensure and Ioniplex (Fig. 3 – Panel D). Furthermore, when added, Ioniplex stimulated the expressions of genes that aid in muscle contraction and motility (measured by quantitative PCR).

Fig. 3 | Mitochondrial Panels
Effect of Ensure (top panel) on metabolic activity in mitochondria of human skeletal muscle cells. Cells incubated with Ensure generated less metabolic activity than cells incubated with Ensure and 200microg of Ioniplex (bottom panel). Note panels B and D show bright field illumination. Magnification x40 with Nikon Eclipse TS100 inverted microscope.

Description of Test: Mitochondrial Metabolism
Report 439

An additional study utilized the colorimetric assay to determine the effects of Ioniplex on mitochondrial metabolism. This test compared the effects of different dosages of Ioniplex with two leading energy drinks, No Fear® and Full Throttle®.


Among test materials, Ioniplex achieved the greatest stimulation, (over 50% at certain concentrations), and was above or on par with No Fear and Full Throttle. Finally, in a cell-based DNA microarray study, where the expression of over 20,000 genes was measured in the absence or presence of Ioniplex, it was established that Ioniplex stimulates a whole array of genes involved in mitochondrial metabolism respiration and ATP production.

Taken together, these results are consistent with the notion of Ioniplex having beneficial activity towards maintaining mitochondrial health.

About Mineral BioSciences

Mineral Biosciences is an affiliate of the larger Global Organics® Group of companies. Founded over 20 years ago on the belief that “Nature Knows Best®,” Global Organics develops signature mineral products that are proven to enhance the health of people, animals, and the environment.

For more information about Mineral BioSciences, or to interview Managing Partner/CEO, Luke Blotsky, please contact Sarah VanWyk at or visit